Current Issue : July- September Volume : 2012 Issue Number : 3 Articles : 2 Articles
Thyroid gland is the major endocrine gland of the body. The pituitary thyroid system is responsible for regulating daily function of many biological systems by producing thyroid hormones, the principal ones being triiodothyronine (T3) and thyroxine. Thyroid hormones (T3, T4) are essential for normal development and growth. The most common problems of the thyroid gland consist of an overactive thyroid gland, referred to as hyperthyroidism, and an underactive thyroid gland, referred to as hypothyroidism. Antithyroid agents can be effectively used in hyperthyroidism. Most commonly used anti-thyroid agents include thioamides, iodides, radioactive iodine and adrenergic blockers. Thyroid gland diseases, their treatment and screening methods of antithyroid agents are discussed briefly in this review....
Gastric ulcer is corrosive action of acid on the mucosa of the upper gastrointestinal tract. Ulcers can develop in the esophagus, stomach or duodenum. Peptic ulcer (PU) disease represents a worldwide health problem due to morbidity, mortality and economic loss. H pylori infection, tobacco smoking, and use of minor tranquillizers were the main risk factors for PU in this population. Researchers develop various screening methods for the study of antiulcer drug development. Out of this screening methods some are used widely such as pylorus ligation, NSAID induced ulcer, stress induced ulcer by immobilization and water immersion, erosion by ethanol and acetic acid. In this present review we discuss the various screening methods used for the antiulcer drug development....
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